MIL OSI – Source: TU Berlin –
Headline: Programme: DFG-Priority Programme „Emerging Roles of Non-coding RNAs in Nervous System Development, Plasticity and Disease” (SPP 1738)
…”Intricate gene regulatory programmes orchestrate both the development of the nervous system as well as experience-dependent adaptations that underlie higher cognitive functions. Very recently, non-coding RNAs (ncRNA) were discovered as an extensive new layer of gene regulation in nervous system function and disease.
The Priority Programme aims at identifying the functionally relevant ncRNA-target interactions, the underlying molecular mechanisms of regulation and the causal links to major neurological diseases. The focus will be on recently “emerging” non-coding RNAs with a documented gene regulatory function (miRNAs, endo-siRNA, piRNAs, lincRNAs). To address ncRNA function and regulation as a function of the spatiotemporal context, investigations will be performed at various stages of nervous system development to adulthood. Various complexity levels will be considered, from molecular machineries via individual cells to the circuit level. The inclusion of different model organisms in the programme will therefore allow to obtain insight into the conservation and evolution of ncRNA mechanisms. Mechanistic projects will focus on action of ncRNAs and its role on transcriptional and/or post-transcriptional regulatory mechanisms in the developing and adult nervous system and the interplay of ncRNAs and RNA-binding proteins (RBPs) and its role in the regulation of ncRNA biogenesis and function. Individual projects should bridge several disciplines, i.e. combining functional analysis with state-of-the-art molecular biology (e.g. massive parallel sequencing), biochemical (e.g. RBP-CLIP, quantitative proteomics) and/or bioinformatics/systems biology (e.g. pathway analysis, ncRNA target prediction) approaches. Therefore, collaboration between participating groups of the programme is strongly encouraged.”…
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(Quelle: DFG Informationen für die Wissenschaft, Nr. 2, 04.01.2017)